Tag Archives: IV PPI Use

PEO Project


Currently, I am working on a directed studies project with a 4th year pharmacy student under the guidance of Dr. Aaron Tejani. We read articles on the inappropriate use of IV PPIs and are in the process of developing a protocol. This is my first time writing a protocol. During undergrad, I always thought it was a daunting task. I am glad I am getting exposed to it now as it would be very helpful when I start writing protocol for my residency project. Until last week I was unfamiliar of the different processes and steps involved in conducing an internal audit and research. For example, for our internal audit we had to submit Fraser Health -Data Access Application and Agreement. Any kind of research or audit requires a lot of planning and paperwork completion. It is a learning process and participating in the directed studies project and residency project is providing me with first hand experience.

I also got a chance to attend a presentation by Dr. Tejani focusing on the risks of proton pump inhibitors. Preparing for PEBCs, I came across fracture risk with use of PPIs, but association of PPIs with risk of Clostridium difficile infection, pneumonia risk and possible risk of acute interstitial nephritis is something I was unaware of. Aaron introduced us to different resources where we can look up generation information on PPIs: http://www.cadth.ca >> COMPUS reports>>Proton pump inhibitor therapy

Oregon Health Sciences University DERP Proton Pump Inhibitor class review

Cochrane Databases

It was interesting and surprising to find out that risk of C.difficile infection is 3 times more even if PPI was used within the past 90 days. Studies have found that use of H2RAs is associated with both Community-acquired pneumonia and Hospital acquired pneumonia whereas PPIs are only associated with community acquired pneumonia.

On Wednesday, we attended Academic Half-Day focusing on Introduction to Infectious Diseases. It was a good review of some concepts and also introduced me to new concepts like non-specific findings, organ/system-specific findings and identification and characterization of pathogen. For example, I was unaware of Kernig’s sign and Brudzinski’s sign (signs and symptoms of meningitis).

On Friday, I got a chance to meet my mentor Anna Yuen, in regards to learning how to use Electronic Medical Records and how to pull reports. We discussed the project and she asked me questions which stimulated me to think of some concepts that I probably won’t have on my own.

I am also working on creating a presentation to introduce other health care professionals to Health-Evidence.ca website.